Question:

Let’s me to know how hold did DHEA-S increased in serum after oral DHEA ingestion. I want to know which is a main compound in serum, DHEA or DHEA-S. Increase over baseline of 6-fold for DHEA is equal or less than those of 6% for DHEA-S!!! – Hide quoted text — Show quoted text ->    Dehydroepiandrosterone (DHEA) is the most abundant steroid hormone in > the body, first identified in urine in 1935. Over 99% of the circulating > DHEA in humans is sulfated (DHEA-S), with less than 1% representing free > steroid. It is secreted by the adrenal gland, >    In order to examine the actual effects of oral DHEA on endocrine and > metabolic parameters in postmenopausal women, 1600 mg/day was given in a > double blind placebo controlled, cross-over study for 28 days. Serum > concentrations of androgens increased rapidly and reached a maximum at > 180-240 minutes, resulting in increases over baseline of 6-fold for DHEA, > 12-fold for androstenedione, 2.5-fold for testosterone, and 15-fold for > dihydrotestosterone. Estrone, estradiol, and sex hormone-binding globulin > (SHBG) were unchanged initially, but both estrone and estradiol showed a > progressive increase to 2-fold the basal value at 4 weeks.

Response:

The following is reprinted from the Townsend Letter for Doctors, by permission.  Those with questions, or interest on the subject may call 360-385-6021 for more information.  Readers of this newsgroup have found information from previous posts interesting.  The editor, Dr. Collin, has agreed to let me post a number of articles each month from his magazine, many more may be found at:    http://www.thorne.com/townsend.html.  Let me know what you think, flame me if you don’t like the stuff.      What